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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of the research design, like recruitment and consent, adherence, and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This kind of heterogeneity is essential for practical trials to be valid and also reduces bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They also provide a useful method of determining the causal relationship between the intervention and its effects. They should not, however be used to replace the need for explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the policy and practice of. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the features of a practical trial, including recruitment, design and delivery of the intervention, and monitoring.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and 프라그마틱 무료슬롯 pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.